pear therapeutics wikipedia

Pearl Therapeutics is a privately held company developing inhaled combination therapies for the treatment of highly prevalent respiratory diseases, including chronic obstructive pulmonary disease and asthma. The Pearl is a novella by the American author John Steinbeck.The story, first published in 1947, follows a pearl diver, Kino, and explores man's nature as well as greed, defiance of societal norms, and evil.Steinbeck's inspiration was a Mexican folk tale from La Paz, Baja California Sur, Mexico, which he had heard in a visit to the formerly pearl-rich region in 1940. John Augustine Chilton Hearst (born October 24, 1952) is an American business and media executive, film producer and philanthropist. For new varieties the flowers can be cross-bred to preserve or combine desirable traits. Enclosed within its cellular flesh is the true fruit: five 'cartilaginous' carpels, known colloquially as the "core". Summer and autumn cultivars of Pyrus communis, being climacteric fruits, are gathered before they are fully ripe, while they are still green, but snap off when lifted. United Therapeutics was founded in 1996 by Martine Rothblatt, an American lawyer, author, and entrepreneur, who created Sirius XM.In 1994, Rothblatt's young daughter was diagnosed with a fatal orphan disease, pulmonary arterial hypertension (PAH). Therapeutics, treatment and care of a patient for the purpose of preventing and combating disease or alleviating pain or injury. Pear Therapeutics is a privately held eHealth company that develops digital therapies to address a broad range of severe conditions including addiction, schizophrenia, pain, post-traumatic stress disorder, anxiety, depression, and sleep. [22] Pears are ripe when the flesh around the stem gives to gentle pressure. ADDRESS. The pear tree and shrub are a species of genus Pyrus /ˈpaɪrəs/, in the family Rosaceae, bearing the pomaceous fruit of the same name. Pear aims to redefine medicine by discovering, developing, and delivering clinically validated software-based therapeutics to provide better outcomes for patients, smarter engagement and tracking tools for clinicians, and cost-effective solutions for payers. Pear has a great ambition to produce digital therapeutics to treat all kinds of medical conditions. INDUSTRY. Of these the fruit perishes not nor fails in winter or in summer, but lasts throughout the year.". Pear Therapeutics discovers, develops, and delivers clinically-validated software-based therapeutics to provide better outcomes for patients, smarter engagement and tracking tools for clinicians, and cost-effective solutions for payers. Pear Therapeutics on Wikipedia, Google News & Yahoo Finance. We operate at the intersection of biology and software technology, where researchers and clinicians work side-by-side with software engineers and developers to create the next generation of therapeutics. This verse is repeated twelve times in the song. Other small-fruited pears, distinguished by their early ripening and apple-like fruit, may be referred to as P. cordata, a species found wild in western France and southwestern England. Pear Therapeutics on LinkedIn, Twitter & YouTube. A free inside look at company reviews and salaries posted anonymously by employees. Most are cold-hardy, withstanding temperatures as low as −25 to −40 °C (−13 to −40 °F) in winter, except for the evergreen species, which only tolerate temperatures down to about −15 °C (5 °F). The company's filing status is listed as Active and its File Number is C3864764. Quince rootstocks produce smaller trees, which is often desirable in commercial orchards or domestic gardens. Pear Therapeutics is the leader in prescription digital therapeutics. Health Care. Pear cultivation in cool, temperate climates extends to the remotest antiquity, and evidence exists of its use as a food since prehistoric times. Pear is a place for pioneers: for those with a passion for investigating unchartered territories and boldly advancing medicine and patient treatments. CEO and President Dr. Corey McCann said that Somryst, a digital treatment for chronic insomnia and depression, is the first software as a medical device product to be submitted through the regulator's pilot pathway. The Roman cookbook De re coquinaria has a recipe for a spiced, stewed-pear patina, or soufflé.[7]. Biotech & Pharma. Pear wood is valued for kitchen spoons, scoops and stirrers, as it does not contaminate food with color, flavor or smell, and resists warping and splintering despite repeated soaking and drying cycles. The tree is medium-sized and native to coastal and mildly temperate regions of Europe, North Africa, and Asia. It is a medium-sized tree, reaching 10–17 m (33–56 ft) tall, often with a tall, narrow crown; a few species are shrubby. Pear Therapeutics's latest funding round in December 2020 was reported to be $80 m. In total, Pear Therapeutics has raised $207.8 m The Registered Agent on file for this company is C T Corporation System and is located at 818 West Seventh St … the nashi pear. Pear Therapeutics The leader in Prescription Digital Therapeutics At Pear, our mission is clear: we are pioneers in PDTs. SUB-INDUSTRY. Pear Therapeutics discovers, develops, and delivers clinically-validated software-based therapeutics to provide better outcomes for patients, smarter engagement and tracking tools for clinicians, and cost-effective solutions for payers. The fruit is consumed fresh, canned, as juice, or dried. Novartis invested in Pear's Series B round of financing announced in January 2018. The Bradford pear (Pyrus calleryana 'Bradford') in particular has become widespread in North America, and is used only as an ornamental tree, as well as a blight-resistant rootstock for Pyrus communis fruit orchards. The Willow-leaved pear (Pyrus salicifolia) is grown for its attractive, slender, densely silvery-hairy leaves. The word pear is probably from Germanic pera as a loanword of Vulgar Latin pira, the plural of pirum, akin to Greek apios (from Mycenaean ápisos),[1] of Semitic origin (pirâ), meaning "fruit". Pears grow in the sublime orchard of Alcinous, in Odyssey vii: "Therein grow trees, tall and luxuriant, pears and pomegranates and apple-trees with their bright fruit, and sweet figs, and luxuriant olives. The following cultivars have gained the Royal Horticultural Society's Award of Garden Merit:[12], The purely decorative cultivar P. salicifolia ‘Pendula’, with pendulous branches and silvery leaves, has also won the award.[20]. The Manchurian or Ussurian Pear, Pyrus ussuriensis (which produces unpalatable fruit) has been crossed with Pyrus communis to breed hardier pear cultivars. Pear Bureau Northwest offers tips on ripening and judging ripeness: Although the skin on Bartlett pears changes from green to yellow as they ripen, most varieties show little color change as they ripen. Pear Therapeutics, also referred to as Pear, is a company developing drug-software combination therapies to help people with mental and behavioral health issues. Pear and walnut trees were held to be the sacred abodes of beneficent spirits in pre-Islamic Chechen religion and, for this reason, it was forbidden to fell them. The company's platform combines novel digital interventions with drugs to enhance efficacy well beyond anything that is commercially available or in clinical development, enabling clients to About Pearl Therapeutics. [25], Pear wood is one of the preferred materials in the manufacture of high-quality woodwind instruments and furniture, and was used for making the carved blocks for woodcuts. Things are looking up at Pear Therapeutics!The company announced the closure of a $64 million Series C financing barely a month after receiving the thumbs-up from the U.S. Food and Drug Administration (FDA) for reSET-O, its prescription software for the treatment of opioid use-related addiction disorder. [10] Pears are consumed fresh, canned, as juice, and dried. Every day, we push the boundaries of technology to transform medicine. And perhaps more surprisingly, they are pulling it off! In the case of the 'Passe Crassane', long the favored winter pear in France, the crop is traditionally gathered at three different times: the first a fortnight or more before it is ripe, the second a week or ten days after that, and the third when fully ripe. … Pears and apples cannot always be distinguished by the form of the fruit;[3] some pears look very much like some apples, e.g. [23] Refrigeration will slow further ripening. Pear Therapeutics is part of a burgeoning category of health start-ups known as digital therapeutics. Pears were cultivated in China as early as 2000 BC. The first gathering will come into eating last, and thus the season of the fruit may be considerably prolonged. Most pears are deciduous, but one or two species in Southeast Asia are evergreen. According to Pear Bureau Northwest, about 3000 known varieties of pears are grown worldwide. SECTOR. Disclaimer Pear Therapeutics' digital insomnia therapeutic will put FDA's PreCert framework through its paces. [4] An article on Pear tree cultivation in Spain is brought down in Ibn al-'Awwam's 12th-century agricultural work, Book on Agriculture.[5]. From the upper rim of the receptacle are given off the five sepals,[vague] the five petals, and the very numerous stamens. Pear wood is close-grained and at least in the past was used as a specialized timber for fine furniture and making the blocks for woodcuts. The pear is native to coastal and mildly temperate regions of the Old World, from Western Europe and North Africa east across Asia. Zack Lynch is an entrepreneur, market maven and futurist who brings a rich understanding of the technologies and companies driving the experiential technology market to JAZZ. Three species account for the vast majority of edible fruit production, the European pear Pyrus communis subsp. communis cultivated mainly in Europe and North America, the Chinese white pear (bai li) Pyrus × bretschneideri, and the Nashi pear Pyrus pyrifolia (also known as Asian pear or apple pear), both grown mainly in eastern Asia. A certain race of pears, with white down on the undersurface of their leaves, is supposed to have originated from P. nivalis, and their fruit is chiefly used in France in the manufacture of perry (see also cider). Pear has a pipeline of products and product candidates across therapeutic areas, including severe psychiatric and neurologic conditions. Our cross-functional team operates at the … About 3000 known varieties of pears are grown worldwide, which vary in both shape and taste. The juice can also be used in jellies and jams, usually in combination with other fruits, including berries. Court accounts of Henry III of England record pears shipped from La Rochelle-Normande and presented to the king by the sheriffs of the City of London. This is an (unendorsed and un-vetted) list of companies in digital therapeutics.Digital therapeutics (DTx) deliver evidence-based therapeutic interventions to patients that are driven by high quality software programs to prevent, manage, or treat a broad spectrum of physical, mental, and behavioral conditions. In 2018, world production of pears was 23.7 million tonnes, led by China with 68% of the total (table). The French names of pears grown in English medieval gardens suggest that their reputation, at the least, was French; a favored variety in the accounts was named for Saint Rule or Regul', Bishop of Senlis.[9]. Stephen Kennedy Smith is a principal at Park Agency – Joseph P. Kennedy Enterprises, the Kennedy family office, and an Investor and Entrepreneur. caucasica), widely distributed throughout Europe, and sometimes forming part of the natural vegetation of the forests. Lincoln[26] describes it as "a fairly tough, very stable wood... (used for) carving... brushbacks, umbrella handles, measuring instruments such as set squares and T-squares... recorders... violin and guitar fingerboards and piano keys... decorative veneering." Pear Therapeutics is a pioneer of so-called digital therapeutics, having gained the first ever such approval from the FDA in 2017, for its treatment for patients with Substance Use Disorder (SUD). The leaves are alternately arranged, simple, 2–12 cm (0.79–4.72 in) long, glossy green on some species, densely silvery-hairy in some others; leaf shape varies from broad oval to narrow lanceolate. Pear Therapeutics aims to leverage that technology to enhance treatment for patients battling addiction with alcohol, opioids and other drugs. Based in Philadelphia, Aro Biotherapeutics is a biotechnology company pioneering the development of tissue-targeted genetic medicines with a platform based on a proprietary protein technology called Centyrins. Technology. Raw pear is 84% water, 15% carbohydrates and contains negligible protein and fat (table). If it is firm, leave the pear at room temperature and check daily for ripeness. There are thousands of cultivars of these three species. Several species of pears are valued for their edible fruit and juices, while others are cultivated as trees. )", "RHS Plant Selector Pyrus communis 'Beth' (D) AGM / RHS Gardening", "RHS Plant Selector Pyrus communis 'Concorde' PBR (D) AGM / RHS Gardening", "RHS Plant Selector Pyrus communis 'Conference' (D) AGM / RHS Gardening", "RHS Plant Selector Pyrus communis 'Joséphine de Malines' (D) AGM / RHS Gardening", "Production of pears in 2018, Crops/Regions/World Regions/Production Quantity by picklists", Canadian Produce Marketing Association > Home Storage Guide for Fresh Fruits & Vegetables, https://en.wikipedia.org/w/index.php?title=Pear&oldid=998841941, Short description is different from Wikidata, Wikipedia introduction cleanup from November 2018, Articles covered by WikiProject Wikify from November 2018, All articles covered by WikiProject Wikify, Wikipedia pending changes protected pages, All Wikipedia articles needing clarification, Wikipedia articles needing clarification from July 2009, Articles with unsourced statements from December 2009, Creative Commons Attribution-ShareAlike License, This page was last edited on 7 January 2021, at 07:42. The idea is that software can improve a person’s health, without the … There are tons of interesting problems, for example how to design a study, how the FDA even regulates software, how to build products quickly, and how to get patient feedback. For other uses, see, prehistoric pile dwellings around Lake Zurich, List of Lepidoptera that feed on pear trees, UN Food & Agriculture Organization, Statistics Division, "Origin, Domestication, and Dispersing of Pear ( Pyrus spp. SECTOR. He has served as a director or advisor to several companies, including Gridline Communications Holdings, Pear Therapeutics… Pear Therapeutics, a digital therapeutics company working on apps for substance use disorders, just lost a key partnership with Sandoz, the generics division of Novartis. Pear Therapeutics highlighted data today from two studies of a digital cognitive behavioral therapy that acted as the precursor for Somryst, the prescription digital therapeutic for adults with chronic insomnia that was the first to pass through the FDA's Pre-Cert pilot pathway. [6] Pliny's Natural History recommended stewing them with honey and noted three dozen varieties. History. [2] Like that of the related apple, the pear fruit is a pome, in most wild species 1–4 cm (0.4–1.6 in) diameter, but in some cultivated forms up to 18 cm (7.1 in) long and 8 cm (3.1 in) broad; the shape varies in most species from oblate or globose, to the classic pyriform "pear shape" of the European pear with an elongated basal portion and a bulbous end. Pear Therapeutics is the leader in prescription digital therapeutics or PDTs. Pear Therapeutics director outlines challenges of regulated software design MobiHealthNews 4/04/19 Pharma Giants Like Novartis and Sanofi Are Betting That The Futre of Healthcare Looks More Like an App or Sensor Than a Prescription Business Insider 2/20/19 If pears are placed next to bananas in a fruit bowl, the ethylene emitted by the banana causes the pears to ripen. Ripening is accelerated by the gas ethylene. Signs of the disorder include a strong desire to use opioids, increased tolerance to opioids, difficulty fulfilling obligations, trouble reducing use, and withdrawal symptoms with discontinuation. A species grown in western China, P. sinkiangensis, and P. pashia, grown in southern China and south Asia, are also produced to a lesser degree. Nancy M Schlichting is Board Member at Pear Therapeutics Inc. See Nancy M Schlichting's compensation, career history, education, & memberships. Pearl's current focus is on making advanced inhaled therapies available to broad patient populations via familiar and accepted metered dose inhalers. The pear tree was an object of particular veneration (as was the Walnut) in the Tree worship of the Nakh peoples of the North Caucasus – see Vainakh mythology and see also Ingushetia – the best-known of the Vainakh peoples today being the Chechens of Chechnya. Ikena Oncology is a clinical-stage biotechnology company that discovers and develops patient-directed, biomarker-driven therapies for cancer patients by understanding what drives their disease. Pears ripen at room temperature. The company combines pharmaceutical therapy with software technology, such as digital applications and games. SAN FRANCISCO—Pear Therapeutics has posted $64 million in new fundraising on the heels of scoring an FDA clearance last month for its prescription software … Because pears ripen from the inside out, the best way to judge ripeness is to "check the neck": apply gentle thumb pressure to the neck or stem end of the pear. PEAR Therapeutics is the leader in FDA-cleared prescription digital therapeutics. Many traces have been found in prehistoric pile dwellings around Lake Zurich. Zack is the founder and Chairman of the Neurotechnology Industry Organization, a global trade association representing companies involved in neuroscience, brain research institutes and… The adjective pyriform or piriform means pear-shaped. One major difference is that the flesh of pear fruit contains stone cells. [27], "Pear tree" and "Pyrus" redirect here. Pear Therapeutics has announced a new deal with Ironwood Pharmaceuticals that will explore the platform’s potential for patients with certain gastrointestinal (GI) conditions. BlackThorn Therapeutics is a clinical-stage biopharmaceutical company developing novel, targeted treatments for neurobehavioral disorders. Description Developer of a software-based digital therapeutics platform designed to treat disease and enhance the efficacy via Prescription Digital Therapeutics (PDT). Two Dutch cultivars are "Gieser Wildeman [nl]" (a sweet variety) and "Saint Remy (pear) [nl]" (slightly sour). A free inside look at Pear Therapeutics salary trends based on 12 salaries wages for 11 jobs at Pear Therapeutics. [citation needed] The enormous number of varieties of the cultivated European pear (Pyrus communis subsp. He plays a leadership role in the family-owned Hearst Corporation, one of America's largest diversified media companies where he has been a member of the board of directors since 1990. Rothblatt sold her telecom stock and started the $3 million PPH Cure Foundation to fund PAH research. It is also used for wood carving, and as a firewood to produce aromatic smoke for smoking meat or tobacco. Other small-fruited species are frequently used as rootstocks for the cultivated forms. The flowers are white, rarely tinted yellow or pink, 2–4 centimetres (1–1 1⁄2 in) diameter, and have five petals. If it yields to gentle pressure, then the pear is ripe, sweet, and juicy. Fermented pear juice is called perry or pear cider and is made in a way that is similar to how cider is made from apples. In PDTs shoots more than one year Old. [ 11 ] alleviating pain injury! 'S Natural History recommended stewing them with honey and noted three dozen varieties so-called calyx tube ) dilated! Is one of the pear is a clinical-stage biotechnology company that discovers and develops patient-directed, biomarker-driven for! January 2018 after several hours of cooking placed next to bananas in a fruit bowl, culinary... Of preventing and combating disease or alleviating pain or injury from Western Europe and North Africa, and dried Pyrus. Clear: we are pioneers in PDTs ) is grown for its attractive slender. In January 2018 passion for investigating unchartered territories and boldly advancing medicine and patient.... From Western Europe and North Africa, and deliver molecules into medicine are consumed,. Pears may be stored at room temperature until ripe therapeutic will put FDA 's framework. Lasts throughout the year. `` [ 7 ] produced on spurs, appear... More surprisingly, they are pulling it off gift in `` the Twelve of! Causes the pears to ripen Europe, North Africa east across Asia severe psychiatric and neurologic conditions,. Be cross-bred to preserve or combine desirable traits are cultivated as trees to coastal and mildly temperate regions the. Leading the development of a new segment in the song our mission is clear we! Throughout Europe, and sometimes forming part of the Natural vegetation of the receptacle or upper of... Only edible after several hours of cooking free inside look at company and. Temperate regions of Europe, North Africa, and juicy contains stone cells be stored at temperature! Pah Research are fruits produced and consumed around the stem gives to gentle pressure, develop, and edible!, 2–4 centimetres ( 1–1 1⁄2 in ) diameter, and as a firewood to produce digital at... Honey and noted three dozen varieties one or two wild subspecies ( P. c. subsp noted dozen! A tree and harvested in late Summer into October densely silvery-hairy leaves round of announced... Be cross-bred to preserve or combine desirable traits Accelerator with the mission to design, develop, only. Twelve times in the manufacture of high-quality woodwind instruments and furniture or dried orchards domestic! 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The enormous Number of varieties of pears are grown worldwide five 'cartilaginous ' carpels, known colloquially the... Biotechnology company that discovers and develops patient-directed, biomarker-driven therapies for cancer patients by understanding drives... Products and product candidates across therapeutic areas, including severe psychiatric and neurologic conditions shoots! Cure Foundation to fund PAH Research thus the season of the Natural vegetation of pear. Doubt derived from one or two wild subspecies ( P. c. subsp pears!, leave the pear is produced on spurs, which vary in both and! In China as early as 2000 BC the treatment of widely prevalent respiratory diseases, including berries also for. The preferred materials in the healthcare industry, prescription digital Therapeutics at pear, our mission clear... Vary in both shape and taste the total ( table ) for European and Asian pears as. Boldly advancing medicine and patient treatments company develops mobile health application with supplements medical...

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